Ledger is supported through the Xverse and Leather Wallet. Check out Xverse's blog for guidance on setting up and utilizing the Ledger, here.
Please note: For Ordinal loans, currently Ledger can only be accessed through the Xverse Wallet. Xverse recommends that only experienced users who have a strong grasp of UTXO management use Xverse and Ledger together.
Note: Ledger is not supported for Rune Loans at the moment. Support is coming soon.